CARiMan - Pheno

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Dr. David Atlan
General Manager
PhenoSystems SA

Rue Rauter 33-34
1070 Bruxelles
Belgium

http://www.phenosystems.com
T. : +32 2 732 5793 or +32 2 736 8359

Fax: +32 2 734 7740
david@phenosystems.com

 

PhenoSystems SA is a young start up company with headquarters in Bois de Villers, Wallonia , and central offices in Brussels . The three founders have the appropriate combination of complementary expertise to develop innovative IT solutions in the genetic / health area as well as to bring them to market. Dr. MD Pascale Benlian is cardiologist and molecular geneticist working at Hospital Saint Antoine in Paris, Dr. David Atlan is a physicist with IT and industrial R&D management ex    perience, and Derek de Villenfagne established as a successful entrepreneur.

PhenoSystems SA is looking forward to participate in PatiMon, improving health of the European Citizen, developing the communication between different disciplines and expertise in fields such as IT, biology, biochemistry, genetics and offering innovative solutions addressing health problems. We could contribute significantly in the area of computer aided diagnostics of genetic diseases as well as knowledge about mutations causing diseases. Information collected in this area has an impact on the evaluation of risk factors as well as the treatment required by patients.

 

CVs

Dr. MD Pascale Benlian

pascale.benlian@sat.ap-hop-paris.fr

MD-PhD, specialized as a cardiologist and as a molecular geneticist. Assistant Professor; Full time tenure at the Department of Biochemistry and Molecular Biology, Saint Antoine Medical School, Paris .

Clinical interest: Consultation mainly focused on familial and complex lipid disorders. Clinical chemistry for the investigation of lipid disorders.

Scientific interest: Molecular genetics of lipid disorders. Coordinator of a French Network for the molecular diagnosis of familial lipid disorders. Improvement of methods to better detect, manage and treat inherited lipid disorders.

Academic achievements: Publications on the molecular genetics of LPL or LCAT deficiency; FH, FDB; modulator alleles of non-cardiovascular diseases (ARMD, PBC); basic studies on the structure of candidate gene loci. Author of didactic books on the genetics of lipid disorders (latest published by Kluwer Academic publishers, Boston , 2001). Editor of the “Med-Ped Newsletter” (2001), suppl. to “Atherosclerosis” on inherited lipid disorders. Member of the executive committee of the EAS, the ELC. Scientific Award winner from the French Academy of Medicine (2001). Member of the Congress Program Committee of the European Society of Cardiology (2002).

Dr David Atlan

Since 2002 : Development of Computer Aided Diagnostics Systems with PhenoSystems SA in the field of genetics.

1995-2002 : R&D and Product Supply management with Procter & Gamble in Belgium and France .

1995: Doctor of Science, Université de Lyon 1. Research on magnetic ultra thin films in ultra high vacuum at Simon Fraser University , Vancouver (Prof. B. Heinrich).

Bourse Lavoisier du Ministère des Affaires Etrangères.

1991: Magistère des Sciences de la Matière, École Normale Supérieure de Lyon. Licence, Maîtrise and DEA Sciences des Matériaux et des Surfaces de Lyon : computational physics in the area of field emission.

Derek de Villenfagne, BBA

Since 1999 : founder and General Manager of Crescential SA, specialised in the development of global brands, such as SpanTech® shelter systems and custom textile architecture, Immoglobe® Real Estate Management and consulting in the area of technology start up projects.

2001 : Prix du jeune Entrepreneur de la Fondation Roi Baudouin for the SpanTech project together with D. Atlan.  

 

Publications

[Pheno1] BENLIAN P., BONAITI C., DOUSTE-BLAZY P., JUNIEN C. Candidate gene approach to type IIa hypercholesterolemia. The Lancet, (1989), vol. I, n° 8648, pp 1201-1202. (L)

 [Pheno2] BENLIAN P., BOILEAU C., LOUX N., PASTIER D., MASLIAH J., COULON M., NIGOU M., RAGAB A., GUIMARD J., RUIDAVETS J.B., BONAÏTI-PELLIÉ C., FRUCHART JC., DOUSTE BLAZY P.,

BÉRÉZIAT G., JUNIEN C. Extended haplotypes and linkage disequilibrium between 11 markers at the ApoAI-CIII-AIV gene cluster on chromosome 11. American Journal of Human

Genetics, (1991), vol 48, n°5, pp 903-910. (O)

[Pheno3] BENLIAN P., Foubert L., GAGNÉ E., BERNARD L., de Gennes JL., LANGLOIS S., ROBINSON W., HAYDEN MR. Complete paternal isodisomy for chromosome 8 unmasked by lipoprotein

lipase deficiency. American Journal of Human Genetics (1996), n° 59, pp 431-436. (O)

[Pheno4] BENLIAN P., de Gennes JL., Foubert L., ZHANG H., GAGNÉ E., HAYDEN MR. Premature atherosclerosis in familial chylomicronemia caused by mutations in the lipoprotein

lipase gene. The New England Journal of Medicine  (1996) , n°335, pp848-854. (O)

[Pheno5] TEH EM., CHISHOLM JW., DOLPHIN PJ., POULIQUEN Y., SAVOLDELLI M., DE GENNES JL., BENLIAN P. Classical LCAT deficiency resulting from a novel homozygous dinucleotide

deletion in exon 4 of the human lecithin:cholesterol acyltransferase gene causing a frameshift and stop codon at residue 144. Atherosclerosis  (1999), n°146, 141-151. (O)

[Pheno6] BENLIAN P.  Genetics of Dyslipidemia. Collection Basic Science for the Cardiologist. Editions KLUWER ACADEMIC PUBLISHERS , Boston MA,  (2001), 320 pages.

[Pheno7] Amsellem S., Briffaut D., Carrié A., Rabès J-P., Girardet J-P., Fredenrich A., Moulin P., Krempf M., Reznik Y., Vialettes B., De Gennes J- L, Brukert E., Benlian P.

[Pheno8] Intronic mutations outside of Alu-repeat rich domains of the LDL receptor gene are a cause of familial hypercholesterolemia. Human Genetics  (2002), n°111 : 501-510. (O)


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